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The present study holds hardiness as the independent variable and depression as the dependent variable. The immunological role of hardiness was ascertained on depression. Sample constituted of 320 people aging 21-- to 65. Subjects were administered hardiness scale and depression scale. Based on the scores obtained on hardiness scale, subjects were categorized specifically into three hardy groups: high, moderate, and low to see their differential effects on depressive feelings. The differences between the means of three hardy groups were found to be significant and the immunological role of hardiness on depression is thoroughly highlighted.