Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals promutagenic DNA repair intermediate
oleh: Melike Çağlayan, Samuel H. Wilson
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-10-01 |
Deskripsi
Incorporation of mismatched nucleotides during DNA replication or repair can lead to mutagenesis. Here the authors reveal that DNA ligase can ligate NHEJ intermediates following incorporation of 8-oxodGTP or dGTP opposite T by DNA Polymerase mu (Pol mu) in vitro, which suggests that Pol mu could cause promutagenic mismatches during DSB repair.