Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6
oleh: Patrick Guye, Mohammad R. Ebrahimkhani, Nathan Kipniss, Jeremy J. Velazquez, Eldi Schoenfeld, Samira Kiani, Linda G. Griffith, Ron Weiss
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-01-01 |
Deskripsi
There has been limited success in generating tissues from human induced pluripotent stem cells (hiPSCs). Here, the authors genetically engineer expression of the transcription factor Gata6 in a single isogenic hiPSC population resulting in complex tissue structures that exhibit liver bud-like properties.