One-pot aminobenzylation of aldehydes with toluenes

oleh: Zhiting Wang, Zhipeng Zheng, Xinyu Xu, Jianyou Mao, Patrick J. Walsh

Format: Article
Diterbitkan: Nature Portfolio 2018-08-01

Deskripsi

Amines are common targets in synthetic chemistry as they often display biological activity. Here, the authors report a one-pot aminobenzylation of aldehydes with readily available toluenes in presence of a sodium amide derivative and a cesium salt additive generating an array of valuable 1,2-diarylethylamine compounds.