Myofibril and mitochondria morphogenesis are coordinated by a mechanical feedback mechanism in muscle

oleh: Jerome Avellaneda, Clement Rodier, Fabrice Daian, Nicolas Brouilly, Thomas Rival, Nuno Miguel Luis, Frank Schnorrer

Format: Article
Diterbitkan: Nature Portfolio 2021-04-01

Deskripsi

Mitochondria produce high amounts of ATP to power myosin motors and sustained muscle contraction. Here, the authors show that during development, muscles coordinate the morphogenesis of their myofibrils directly with their mitochondria to optimize both for the physiological needs of each muscle-type.