Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis
oleh: Jonathan Martínez-Fábregas, Alan Prescott, Sander van Kasteren, Deena Leslie Pedrioli, Irwin McLean, Anna Moles, Thomas Reinheckel, Valeria Poli, Colin Watts
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-12-01 |
Deskripsi
How cells regulate their lysosomal proteolytic capacity is only partly understood. Here, the authors show that lysosomal protease deficiency or substrate overload induces lysosomal stress leading to activation of a STAT3-dependent, TFEB-independent pathway of lysosomal hydrolase expression.