Wireless, battery-free, multifunctional integrated bioelectronics for respiratory pathogens monitoring and severity evaluation
oleh: Hu Li, Huarui Gong, Tsz Hung Wong, Jingkun Zhou, Yuqiong Wang, Long Lin, Ying Dou, Huiling Jia, Xingcan Huang, Zhan Gao, Rui Shi, Ya Huang, Zhenlin Chen, Wooyoung PARK, Ji Yu Li, Hongwei Chu, Shengxin Jia, Han Wu, Mengge Wu, Yiming Liu, Dengfeng Li, Jian Li, Guoqiang Xu, Tianrui Chang, Binbin Zhang, Yuyu Gao, Jingyou Su, Hao Bai, Jie Hu, Chun Ki Yiu, Chenjie Xu, Wenchuang Hu, Jiandong Huang, Lingqian Chang, Xinge Yu
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2023-11-01 |
Deskripsi
Abstract The rapid diagnosis of respiratory virus infection through breath and blow remains challenging. Here we develop a wireless, battery-free, multifunctional pathogenic infection diagnosis system (PIDS) for diagnosing SARS-CoV-2 infection and symptom severity by blow and breath within 110 s and 350 s, respectively. The accuracies reach to 100% and 92% for evaluating the infection and symptom severity of 42 participants, respectively. PIDS realizes simultaneous gaseous sample collection, biomarker identification, abnormal physical signs recording and machine learning analysis. We transform PIDS into other miniaturized wearable or portable electronic platforms that may widen the diagnostic modes at home, outdoors and public places. Collectively, we demonstrate a general-purpose technology for rapidly diagnosing respiratory pathogenic infection by breath and blow, alleviating the technical bottleneck of saliva and nasopharyngeal secretions. PIDS may serve as a complementary diagnostic tool for other point-of-care techniques and guide the symptomatic treatment of viral infections.