Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells
oleh: Holly Rore, Nicholas Owen, Raul Eduardo Piña-Aguilar, Kevin Docherty, Ryohei Sekido
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-06-01 |
Deskripsi
Rore et al generate testicular somatic cell-like cells (TesLCs) including Sertoli cell-like cells from mouse embryonic stem cells in xeno-free culture. They created testicular organoids in aggregation co-culture of TesLCs and epiblast-like cells (EpiLCs) and also find that TesLC-conditioned media promotes the differentiation of EpiLCs into primordial germ-like cells (PGCLCs).