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In this manuscript, we propose some sufficient conditions for the existence of solution for the multivalued orthogonal ℱ-contraction mappings in the framework of orthogonal metric spaces. As a consequence of results, we obtain some interesting results. Also as application of the results obtained, we investigate Ulam’s stability of fixed point problem and present a solution for the Caputo-type nonlinear fractional integro-differential equation. An example is also provided to illustrate the usability of the obtained results.