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The paper shows that the Caputo definition of fractional differentiation is problematic if it is used in the definition of a time fractional model and if initial conditions are taken into account. The demonstration is done using simple examples (or counterexamples). The analysis is extended to the Riemann-Liouville and Grünwald-Letnikov definitions. These results thus question the validity of results produced in the field of time fractional model analysis in which initial conditions are involved.