Find in Library

Objective To study the protective effect of baicalin on oxidative stress⁃ induced gingival epithelial cell apoptosisand its mechanism. Methods H2O2 was employed to form the oxidative stress ⁃ induced gingival epithelial cells apoptotic model, with the intervention of baicalin. The cell proliferation rate, cell apoptosis level, the protein ex⁃ pression of protein kinase B (Akt) and glycogen synthase kinase3β (GSK3β) were investigated respectively. Results Baicalin could effectively alleviate oxidative stress⁃induced inhibition of gingival epithelial cell proliferation and allevi⁃ ate apoptosis; and it could promote the phosphorylation of Akt⁃GSK3β signaling pathway. Conclusion Baicalin has a significant protective effect on oxidative stress⁃induced apoptosis of gingival epithelial cells, which may be related to the regulation of Akt⁃GSK3β signal pathway.