Durable response to programmed death-1 (PD-1) blockade in a metastatic gastric cancer patient with mismatch repair deficiency and microsatellite instability
oleh: Ting-Hui Wu, Emily Han-Chung Hsiue, Chang-Tsu Yuan, Li-Hui Tseng, Chia-Chi Lin, Kun-Huei Yeh
| Format: | Article |
|---|---|
| Diterbitkan: | Wolters Kluwer Medknow Publications 2017-06-01 |
Deskripsi
Mismatch repair deficiency (dMMR) or microsatellite instability (MSI) has been reported as a predictive biomarker for responses to programmed death-1 (PD-1) blockade in metastatic colorectal cancer. A high response rate to anti-PD-1 therapy was observed in other cancer types with MSI. We report a chemotherapy-refractory metastatic gastric cancer patient with dMMR and MSI who responded remarkably well to pembrolizumab, a PD-1 monoclonal antibody. The satisfactory objective response has lasted for more than 24 months as of this report.