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Abstract Liposuction is not a risk‐free procedure and potentially fatal complications may occur, especially liposuction‐induced fat embolism syndrome (FES). Here we report the case of a 29‐year‐old woman who developed FES suddenly during a liposuction operation in a cosmetic medical clinic. She was transferred to the hospital and achieved complete recovery within 11 days by comprehensive therapeutic strategies, including noninvasive ventilation (NIV), corticosteroids, albumin, diuretics and anticoagulation. Liposuction‐induced FES is a life‐threatening condition, which can be treated with complate recovery by comprehensive therapeutic strategies according to its pathophysiologic mechanism.