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Systemic AA amyloidosis is an uncommon complication of rheumatoid arthritis (RA), especially in poorly controlled RA. Renal involvement caused by deposits of amyloid fibrils derived from acute-phase proteins is represented by nephrotic-range proteinuria ultimately leading to renal failure. We report the case of 27-year-old woman diagnosed with RA, with a history of musculoskeletal involvement since the age of 16, manifested by arthritis involving the wrists, knees and ankles; accompanied by severe and persistent inflammatory syndrome. She presented with an active form of RA complicated with secondary amyloidosis manifested by nephrotic-range proteinuria at the time of admission. Renal biopsy confirmed the presence of amyloid deposits. Anti-TNFα therapy with Certolizumab pegol proved effective in reducing proteinuria and inflammatory biomarker levels in our patient. The efficacy of anti TNF-α therapy in RA complicated with renal amyloidosis is demonstrated by recent scientific data.