Switching from TNF-induced inflammation to death signaling
oleh: Qing Xu, Swati Choksi, Zhengang Liu
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2018-01-01 |
Deskripsi
TNFR1-mediated cell signaling involves complex molecular pathways leading to inflammation and death. Cytosolic RARĪ³ plays a pivotal role in converting TNF-induced inflammatory responses to RIP1 initiated cell death and this finely regulated function of RARĪ³ serves as a checkpoint to engage death pathways in response to TNF.