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This study aims to identify molecular marker loci that could be applied in broiler breeding programs. In this study, we used public databases to locate the <i>Transcription factor 21</i> (<i>TCF21</i>) gene that affected the economically important traits in broilers. Ten single nucleotide polymorphisms were detected in the <i>TCF21</i> gene by monoclonal sequencing. The polymorphisms of these 10 SNPs in the <i>TCF21</i> gene were significantly associated (<i>p</i> < 0.05) with multiple growth and body composition traits. Furthermore, the <i>TT</i> genotype of g.-911T>G was identified to significantly increase the heart weight trait without affecting the negative traits, such as abdominal fat and reproduction by multiple methods. Thus, it was speculated that the g.-911T>G identified in the <i>TCF21</i> gene might be used in marker-assisted selection in the broiler breeding program.