Pathogenic mechanisms involving the interplay between adipose tissue and auto-antibodies in rheumatoid arthritis
oleh: Iván Arias-de la Rosa, Alejandro Escudero-Contreras, Miriam Ruiz-Ponce, Laura Cuesta-López, Cristóbal Román-Rodríguez, Carlos Pérez-Sánchez, Patricia Ruiz-Limón, Rocío Guzman- Ruiz, Fernando Leiva-Cepas, Juan Alcaide, Pedro Segui, Chamaida Plasencia, Ana Martinez-Feito, Pilar Font, María C. Ábalos, Rafaela Ortega, María M. Malagón, Francisco J. Tinahones, Eduardo Collantes-Estévez, Chary López-Pedrera, Nuria Barbarroja
| Format: | Article |
|---|---|
| Diterbitkan: | Elsevier 2022-09-01 |
Deskripsi
Summary: We aimed to evaluate the association between adipose tissue (AT) dysfunction, autoimmunity, and disease activity in rheumatoid arthritis (RA). A cross-sectional study including 150 RA patients and 50 healthy donors and longitudinal study with 122 RA patients treated with anti-tumor necrosis factor (TNF)-α, anti-interleukin 6 receptor (IL6R) or anti-CD20 therapies for 6 months were carried out. In vitro experiments with human AT and adipocyte and macrophage cell lines were performed. A collagen-induced arthritis mouse model was developed. The insulin resistance and the altered adipocytokine profile were associated with disease activity, the presence of anti-citrullinated proteins anti-bodies (ACPAs), and worse response to therapy in RA. AT in the context of arthritis is characterized by an inflammatory state alongside the infiltration of macrophages and B/plasmatic cells, where ACPAs can have a direct impact, inducing inflammation and insulin resistance in macrophages and promoting a defective adipocyte differentiation, partially restored by biologicals.