Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions
oleh: Maxwell W. Brown, Yoori Kim, Gregory M. Williams, John D. Huck, Jennifer A. Surtees, Ilya J. Finkelstein
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-02-01 |
Deskripsi
DNA-binding proteins need to scan the genome to find their targets though how this occurs in the crowded nuclear environment is poorly understood. Here the authors use single-molecular fluorescence to show the repair complex Msh2-Msh3 can hop over blocks that impede the sliding complex Msh2-Msh6.