Highly Substituted Phenol Derivatives with Nitric Oxide Inhibitory Activities from the Deep-Sea-Derived Fungus <i>Trichobotrys effuse</i> FS524
oleh: Shanchong Chen, Zhaoming Liu, Yuchan Chen, Haibo Tan, Saini Li, Hongxin Liu, Weimin Zhang, Shuang Zhu
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2020-02-01 |
Deskripsi
Chemical investigation on EtOAc extract of the deep-sea-derived fungus <i>Trichobotrys effuse </i>FS524 resulted in the isolation of six new highly substituted phenol derivatives trieffusols A−F (<b>1</b>−<b>6</b>), along with ten known relative analogues (<b>7</b>−<b>16</b>). Their structures with absolute configurations were extensively characterized on the basis of spectroscopic data analyses, single-crystal X-ray diffraction experiments, and electronic circular dichroism (ECD) calculations. Structurally, trieffusols A and B shared an unprecedented ploy-substituted 9-phenyl-hexahydroxanthone skeleton with an intriguing 6-6/6/6 tetracyclic fused ring system, which were often encountered as significant moieties in the pharmaceutical drugs but rarely discovered in natural products. In the screening towards their anti-inflammatory activities of <b>1</b>−<b>6</b>, trieffusols C and D exhibited moderate inhibitory activities against nitric oxide (NO) production in LPS-induced RAW 264.7 macrophages with IC<sub>50</sub> values ranging from 51.9 to 55.9 <i>μ</i>M.