Differential expansion of T central memory precursor and effector subsets is regulated by division speed
oleh: Lorenz Kretschmer, Michael Flossdorf, Jonas Mir, Yi-Li Cho, Marten Plambeck, Irina Treise, Albulena Toska, Susanne Heinzel, Matthias Schiemann, Dirk H. Busch, Veit R. Buchholz
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-01-01 |
Deskripsi
T cell responses start with antigen-induced rapid cell divisions, and end by division cessation after pathogen clearance. Here, the authors use single-cell fate mapping and nucleoside analogue labelling to show that T central memory precursors proliferate slower than effector subsets and rely on antigenic rather than inflammatory stimuli to maintain their cell cycle speed.