Mettl3-dependent m6A modification attenuates the brain stress response in Drosophila
oleh: Alexandra E. Perlegos, Emily J. Shields, Hui Shen, Kathy Fange Liu, Nancy M. Bonini
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-09-01 |
Deskripsi
The brain is vulnerable to stress and disease, with much work focused on defining mechanisms that impact the brain’s resilience. Here the author’s reveal in Drosophila that m6A epitranscriptomic modification of RNA dampens the brain’s capacity to mitigate stress by regulating RNA stability and translation.