Find in Library

Three new (<b>1</b>–<b>3</b>) and 25 known compounds were isolated from the crude extract of <i>Cassia abbreviata</i>. The chemical structures of new compounds were established by extensive spectroscopic analyses including 1D and 2D NMR and HRESIMS. Cassiabrevone (<b>1</b>) is the first heterodimer of guibourtinidol and planchol A. Compound <b>2</b> was a new chalcane, while <b>3</b> was a new naphthalene. Cassiabrevone (<b>1</b>), guibourtinidol-(4α→8)-epiafzelechin (<b>4</b>), taxifolin (<b>8</b>), oleanolic acid (<b>17</b>), piceatannol (<b>22</b>), and palmitic acid (<b>28</b>), exhibited potent anti-HIV-1 activity with IC₅₀ values of 11.89 µM, 15.39 µM, 49.04 µM, 7.95 µM, 3.58 µM, and 15.97 µM, respectively.