Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs
oleh: Maoyi Lai, Alicia Gonzalez-Martin, Anthony B. Cooper, Hiroyo Oda, Hyun Yong Jin, Jovan Shepherd, Linling He, Jiang Zhu, David Nemazee, Changchun Xiao
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-08-01 |
Deskripsi
MicroRNA cluster 17∼92 plays a critical role in B-cell differentiation. Here the authors show that miR-19 regulates B-cell tolerance via suppressing the expression of PTEN, whereas miR- 17 is essential for early B-cell development independently of Pten, Phlpp2, or Bim.