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The periorbital region has a complex anatomy and the reconstruction process of this area requires a precise approach, in order to preserve vision and offer a good esthetic aspect. The pathological processes that occur in this area are diverse and include trauma, tumors, burns, radiation, infections and congenital anomalies. This paper presents the surgical experience of a plastic surgery department in choosing the proper surgery for reconstructing periorbital defects after tumors excision and the possible complications. The used methods were local advancement and rotational flaps associated with full thickness skin grafts in small defects. Regarding postoperative complications, ectropion developed in one patient that was corrected in another surgery. Periocular reconstruction surgery depends not only on the defect zone, thickness and general status of the patient but also on the surgeon’s experience. The main goal is to restore the periocular structures functions in order to achieve protection of eye surface and to preserve the visual acuity.