Spinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by Grhl2
oleh: Evanthia Nikolopoulou, Caroline S. Hirst, Gabriel Galea, Christina Venturini, Dale Moulding, Abigail R. Marshall, Ana Rolo, Sandra C. P. De Castro, Andrew J. Copp, Nicholas D. E. Greene
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-06-01 |
Deskripsi
Loss or over-expression of Grainyhead-like transcription factors (Grhl) prevents closure of the neural tube but the mechanism underlying this is unclear. Here, the authors show that Grhl2 regulates murine posterior-neuropore closure via changes in the identity and biomechanics of the non-neural, surface ectoderm cells.