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Herein, a compact, low profile flexible wearable antenna with an AMC (Artificial Magnetic Conductor) embedded structure is presented. The proposed AMC-integrated antenna is fabricated using layers of leather and operates at the Industrial Scientific Medical (ISM) 5.8 GHz band. The overall dimension of the low-profile AMC antenna is 40.5×40.5×6 mm3. AMC structure is incorporated to reduce the backward scattering wave toward the human body which in turn increases the gain to 7.47 dB and reduces the specific absorption rate (SAR) about 90%. The fabricated antenna prototype with the integrated AMC is investigated by placing it on different parts of the human body. The performance studies of the AMC backed antenna also reveals that it can tolerate the loading due to the bent surface as well as the crumpled surface. The obtained results show that the proposed antenna is safe and suitable for biomedical applications.