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Hypervitaminosis A Induced First Arch Syndrome
oleh: Mahdi Jalali, Jafar Golalipour, Alireza Fazel
Format: | Article |
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Diterbitkan: | Hamadan University of Medical Sciences 1999-03-01 |
Deskripsi
In this study we examine the effect(s) of excess vitamin A on developing first branchial arch. Intraperitoneal administration of 10000 u/Kg of vitamin A at zero and 12 hrs, on day of gestation (vaginal plug = zero) induced high incidences of craniofacial defect such as mandibular hypoplasia and cleft palate. It is well known that distruption among the neural crest cells migration and/or differentiation during face formation might cause facial malformation. Based on our results, we may conclude that excess vitamin A probably interfere with crest cells migration in cranifacial as it may induced excess cell death. The later phenomena may also cause facial defects.