JNK regulates muscle remodeling via myostatin/SMAD inhibition
oleh: Sarah J. Lessard, Tara L. MacDonald, Prerana Pathak, Myoung Sook Han, Vernon G. Coffey, Johann Edge, Donato A. Rivas, Michael F. Hirshman, Roger J. Davis, Laurie J. Goodyear
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-08-01 |
Deskripsi
Endurance and resistance exercise have different effects on skeletal muscle phenotype. Using mouse models and human subjects, the authors show that JNK/Smad2 signaling acts as molecular switch that when activated by resistance exercise leads to hypertrophy, and when inhibited promotes endurance adaptations in muscle.