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Background: The brachioradial artery is one of the most frequently encountered anatomical variations of the vasculature in the upper extremities. The presence of such may alter the success rate of neurovascular diagnostic procedures and therapeutic strategies. Case description: We present two adult patients with cerebral vascular lesions who underwent follow-up cerebral angiogram through a transradial approach. Both patients had brachioradial arteries through which a diagnostic angiogram was performed successfully. Conclusions: A brachioradial artery is an important variant to consider and recognize when performing neurovascular interventions. It is crucial to get familiarized with such vasculature to avoid a problematic or unsuccessful access. Keywords: Brachioradial artery, Neuroendovascular interventions, Radial artery, Transradial approach