Find in Library

A new linear polyketide, named aspormisin A (<b>1</b>), together with five known polyketides (<b>2</b>–<b>6</b>), were isolated from the alga-derived fungus <i>Aspergillus ochraceopetaliformis</i> SCSIO 41020. Their structures were elucidated through a detailed comprehensive spectroscopic analysis, as well as a comparison with the literature. An anti-inflammatory evaluation showed that compounds <b>2</b>, <b>5</b>, and <b>6</b> possessed inhibitory activity against the excessive production of nitric oxide (NO) and pro-inflammatory cytokines in LPS-treated RAW 264.7 macrophages in a dose-dependent manner without cytotoxicity. Further studies revealed that compound <b>2</b> was active in blocking the release of pro-inflammatory cytokines (IL-6, MCP-1, and TNF-α) induced by LPS both in vivo and in vitro. Our findings provide a basis for the further development of linear polyketides as promising anti-inflammatory agents.