Find in Library

The aim of the research is to analyze glomerular and tubular epithel changes in Gentamicin nephrotoxicity. Degenerative changes were detected in cortex of animals treated by Gentamicin were detected (100 mg/kg body mass/24 h). The nephron morphological changes were the most intensified in tubular system: as desquamation of proximal tubules and necrosis in glomerular capillary loops. In animals, treated by Gentamicin the decreasing of sodium serum concentration (p<0,01) and potassium (p<0,05) took place while there was the increasing of urea (p<0,001) and creatinine (p<0,001) comparing to the control group. Our biochemical and morphological findings support hypothesis that Gentamicin causes exacerbation of renal function and lead to kidney insufficiency.