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<strong>Objective</strong> To analyze the application of hybrid treatment for complicated carotid artery stenosis and occlusion and explore its clinical significance. <strong>Methods</strong> The clinical data of 12 patients, including 8 carotid artery occlusion patients and 4 multilevel carotid artery stenosis patients, who received hybrid treatment during the surgery were analyzed, and the efficacy and safety of combined surgical techniques were explored. <strong>Results</strong> For 8 carotid artery occlusion patients, 7 procedures were successful. For 4 multilevel carotid artery stenosis patients, all procedures were successful. They underwent both carotid endartertectomy (CEA) and common carotid artery angioplasty during the surgery. There was no neurological morbidity or mortality after operation. <strong>Conclusions</strong> Intraoperative angioplasty combined with CEA (hybrid treatment) is an effective and safe method for carotid artery occlusion or multilevel carotid artery stenosis. <br />doi：10.3969/j.issn.1672-6731.2014.02.005<br />