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A Tractable and Efficient One-Pot Synthesis of 5'-Azido-5'-deoxyribonucleosides
oleh: Theodore V. Peterson, Tobin U. B. Streamland, Ahmed M. Awad
Format: | Article |
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Diterbitkan: | MDPI AG 2014-02-01 |
Deskripsi
Synthetic routes to 5'-azidoribonucleosides are reported for adenosine, cytidine, guanosine, and uridine, resulting in a widely applicable one-pot methodology for the synthesis of these and related compounds. The target compounds are appropriate as precursors in a variety of purposive syntheses, as the synthetic and therapeutic relevance of azido- and amino-modified nucleosides is expansive. Furthermore, in the conversion of alcohols to azides, these methods offer a tractable alternative to the Mitsunobu and other more difficult reactions.