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Introduction: The HIV pandemic had a prevalence of 0.27% with 20.9 lakhs PLHIV in the year 2011.Decreased CD4 counts and associated opportunistic infections affects their Quality of Life. Objective: The objective of the study was to assess the association between CD4 counts and Quality of Life (QOL). Material and Methods: A cross-sectional study was conducted among 558 subjects visiting ART centre of Burdwan Medical College aged ≥ 15 years. Information regarding Socio-demographic variables was taken and Quality of Life (QOL) assessed by WHOQOL-BREF (Bengali version). Results and Analysis: Majority of the 558 subjects were Male (6.9%), Hindu (80.1%) and aged between 25-34 years (44.6%). 32.6% subjects had CD4 count < 200 mm3. Increased CD4 count was associated with higher QOL which was found to be statistically significant. Conclusion: QOL of HIV patient is influenced to a great extent by CD4 Count