Synthetic biology-instructed transdermal microneedle patch for traceable photodynamic therapy
oleh: Gang He, Yashi Li, Muhammad Rizwan Younis, Lian-Hua Fu, Ting He, Shan Lei, Jing Lin, Peng Huang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-10-01 |
Deskripsi
An effective delivery system and imaging method for 5-Aminolevulinic acid (5-ALA)-based photodynamic therapy facilitated by the conversion of 5-ALA to protoporphyrin IX (PpIX) are lacking. Here, reversing the hypoxic tumour microenvironment can increase the in vivo biosynthesis of PpIX through the regulation of PpIX-related synthetases for traceable photodynamic therapy.