Redox-dependent Igfbp2 signaling controls Brca1 DNA damage response to govern neural stem cell fate
oleh: Weam S. Shahin, Shima O. Ebed, Scott R. Tyler, Branko Miljkovic, Soon H. Choi, Yulong Zhang, Weihong Zhou, Idil A. Evans, Charles Yeaman, John F. Engelhardt
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-01-01 |
Deskripsi
How reactive oxygen species regulate neuronal stem cell (NSC) behavior is poorly understood. Here, the authors report that Ncf1-dependent oxidation of Igfbp2 cystines represses DNA repair networks to regulate NSC self-renewal and cell fate decisions.