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Four compounds namely Fenor (F-760), Strom, salicylic acid (SA) and thiamin (B1) were tested against root rot disease of wheat under field condition. Wheat grains were soaked in these compounds for 6 h before sowing. Mean disease rating, disease appearance, and distribution of disease were estimated as parameters of disease severity. All tested compounds significantly reduced the root rot of wheat severity during seedling, flowering and ripening stages. Fresh and dry weights were also affected by application of these compounds. Water maintenance capacity in all stages was increased as a result of seed treatments by the above-mentioned compounds. Crop yield and parameters of spikes and grains were significantly improved. These results were discussed and analyzed statistically using LSD test.