A point mutation in HIV-1 integrase redirects proviral integration into centromeric repeats
oleh: Shelby Winans, Hyun Jae Yu, Kenia de los Santos, Gary Z. Wang, Vineet N. KewalRamani, Stephen P. Goff
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-03-01 |
Deskripsi
HIV-1 integration sites are biased towards actively transcribed genes, likely mediated by binding of the viral integrase (IN) protein to host factors. Here, Winans et al. show that the K258R point mutation in IN eredirects viral DNA integration to the centromeres of host chromosomes, which may affect HIV latency.