Hsp90 Inhibitors Prevent HSV-1 Replication by Directly Targeting UL42-Hsp90 Complex
oleh: Shurong Qin, Shurong Qin, Shurong Qin, Shurong Qin, Xiao Hu, Xiao Hu, Xiao Hu, Xiao Hu, Shimin Lin, Shimin Lin, Shimin Lin, Ji Xiao, Ji Xiao, Ji Xiao, Zhaoyang Wang, Zhaoyang Wang, Zhaoyang Wang, Jiaoyan Jia, Jiaoyan Jia, Jiaoyan Jia, Xiaowei Song, Xiaowei Song, Xiaowei Song, Kaisheng Liu, Zhe Ren, Zhe Ren, Zhe Ren, Yifei Wang, Yifei Wang, Yifei Wang
| Format: | Article |
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| Diterbitkan: | Frontiers Media S.A. 2022-02-01 |
Deskripsi
Herpes simplex virus type I (HSV-1) is a member of the Alphaherpesvirinae family, which could initiate labial herpes caused by the reactivation of HSV-1 primary infection, and secondary infection even causes herpes encephalitis. The study presented here demonstrates that Hsp90 inhibitors (AT-533 and 17-AAG) directly targeted the HSV-1 UL42-Hsp90 complex, and Hsp90 interacted with HSV-1 UL42 in silicon and experiment. Interestingly, Hsp90 inhibitors also reduced virus titers of ACV-resistant clinical HSV-1 strains (153 and blue strain), revealing that HSV-1 UL42 would be a new target against ACV-resistant HSV-1 strains. Altogether, this present study indicates that Hsp90 inhibitors prevent HSV-1 proliferation by regulating the interaction between Hsp90 and HSV-1 UL42, suggesting a promising target for anti-HSV-1 therapies in the replication.