PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation

oleh: Yu-Ting Yen, May Chien, Pei-Yi Wu, Shih-Chieh Hung

Format: Article
Diterbitkan: Nature Portfolio 2021-06-01

Deskripsi

Yen et al use tissue-specific PP2A knockout mice to show that PP2A in LepR positive mesenchymal stem cells positively regulates endochondral ossification. They find that PP2A dephosphorylates Runx2 and BRD4, thereby playing a major role in positively and negatively regulating osteogenesis and adipogenesis, respectively.