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There are two independent molecules in the asymmetric unit of the title compound, C22H21N3O4S. The central benzene ring makes dihedral angles of 74.28 (6) and 68.84 (6)° with the pyridine and 3,5-dimethoxyphenyl rings, respectively, in one molecule [86.66 (6) and 81.14 (6)° respectively, in the other]. Each of the molecules forms a centrosymmetric dimer with another molecule via pairs of intermolecular N—H...O hydrogen bonds. These hydrogen bonds connect the N—H groups and the O atoms of the carbonyl groups next to the 3,5-dimethoxyphenyl rings. Additional intermolecular N—H...O interactions link the dimers in the crystal structure.