EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming
oleh: Nicolas Istaces, Marion Splittgerber, Viviana Lima Silva, Muriel Nguyen, Séverine Thomas, Aurore Le, Younes Achouri, Emilie Calonne, Matthieu Defrance, François Fuks, Stanislas Goriely, Abdulkader Azouz
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-07-01 |
Deskripsi
T box transcription factor Eomesodermin (EOMES) is induced when naïve T cells are converted to innate memory T cells in response to cytokines. Here the authors show that EOMES is recruited to RUNX3-bound enhancers and interacts with BRG1 during innate memory T cell formation.