A single donor is sufficient to produce a highly functional in vitro antibody library
oleh: M. Frank Erasmus, Sara D’Angelo, Fortunato Ferrara, Leslie Naranjo, André A. Teixeira, Rebecca Buonpane, Shaun M. Stewart, Horacio G. Nastri, Andrew R. M. Bradbury
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-03-01 |
Deskripsi
Here, the authors construct and validate an in vitro antibody library from a single, healthy donor. They demonstrate the functionality of the library using several therapeutically relevant targets and were able to obtain many different antibodies with the desired biophysical properties.