Many dissimilar NusG protein domains switch between α-helix and β-sheet folds

oleh: Lauren L. Porter, Allen K. Kim, Swechha Rimal, Loren L. Looger, Ananya Majumdar, Brett D. Mensh, Mary R. Starich, Marie-Paule Strub

Format: Article
Diterbitkan: Nature Portfolio 2022-07-01

Deskripsi

Folded proteins are composed of secondary structures, α-helices and β-sheets, that are generally assumed to be stable. Here, the authors combine computational prediction with experimental validation to show that many sequence-diverse NusG protein domains switch completely from α-helix to β-sheet folds.