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This study was conducted for examine the histological effects of aflatoxin and <em>Toxoplasma gondii </em>on some organs like liver, heart, kidney and brain in mice. Were , mice divided into six equal groups; group 1 (untreated control), group 2 were injected intraperitonealy with <em>T. gondii </em>tissue cysts, group 3 fed diets contaminated with 0.5 ppm of aflatoxin, group 4 were fed diets contaminated with 1 ppm aflatoxin, group 5 were fed 0.5 ppm of aflatoxin and injected with <em>T. gondii </em>cysts and group 6 were fed 1 ppm aflatoxin with injected <em>T. gondii </em>tissue cysts. The experiment maintained for 40 days. At the end of the experiment, histological changes were increased specially at groups 5 and 6 including necrosis and lymphocytic infiltration, there are significantly increased in the level of MDA and significantly decrease of GSH level in liver tissue specially in groups (2) and (4) as compared with group (1) normal healthy control.