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Advanced Glycation End Products and Their Effect on Vascular Complications in Type 2 Diabetes Mellitus
oleh: Jeongmin Lee, Jae-Seung Yun, Seung-Hyun Ko
Format: | Article |
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Diterbitkan: | MDPI AG 2022-07-01 |
Deskripsi
Diabetes is well established as a chronic disease with a high health burden due to mortality or morbidity from the final outcomes of vascular complications. An increased duration of hyperglycemia is associated with abnormal metabolism. Advanced glycation end products (AGEs) are nonenzymatic glycated forms of free amino acids that lead to abnormal crosslinking of extra-cellular and intracellular proteins by disrupting the normal structure. Furthermore, the interaction of AGEs and their receptors induces several pathways by promoting oxidative stress and inflammation. In this review, we discuss the role of AGEs in diabetic vascular complications, especially type 2 DM, based on recent clinical studies.