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Xin Liu,1 Lili An,2 Yonghui Zhou,1 Wei Peng,1 Cong Huang1 1College of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang City, People’s Republic of China; 2Dermatology Department, the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang City, People’s Republic of ChinaCorrespondence: Xin Liu, College of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang City, People’s Republic of China, Tel +8618886056643, Email 1046977102@qq.comPurpose: Staphylococcus epidermidis has become one of the most common causes of septicemia. Meanwhile, S. epidermidis has acquired resistance to many antibiotics. Among these, methicillin-resistant S. epidermidis (MRSE) were frequently isolated. Similar to methicillin resistant Staphylococcus aureus (MRSA), they also exhibited multi-resistance, which presented a danger to human health. Patrinia scabiosaefolia as traditional Chinese medicine had strong antibacterial activity against MRSE. However, the mechanism of P. scabiosaefolia against MRSE is not clear.Methods: Here, the morphology of cell wall and cell membrane, production of β-lactamase and PBP2, energy metabolism, antioxidant system were systematically studied.Results: The data showed that P. scabiosaefolia damaged the cell wall and membrane. In addition, β-lactamase, energy metabolism and antioxidant system were involved in mechanisms of P. scabiosaefolia against MRSE.Conclusion: These observations provided new understanding of P. scabiosaefolia against MRSE to control MRSE infections.Keywords: methicillin-resistantStaphylococcus epidermidis, Patrinia scabiosifolia, β-lactamase, energy metabolism, antioxidant system