The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization
oleh: Feng Zhang, Claudia Prahst, Thomas Mathivet, Laurence Pibouin-Fragner, Jiasheng Zhang, Gael Genet, Raymond Tong, Alexandre Dubrac, Anne Eichmann
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-11-01 |
Deskripsi
Robo4 is a transmembrane protein that regulates vascular permeability. Zhang et al. now reveal the mechanism of Robo4 action and show that Robo4 and UncB are required for VEGF-mediated regulation of vascular barrier by suppressing VEGF-induced phosphorylation of its receptor Vegfr2 on Y949.