Engineering enhanced cellobiohydrolase activity

oleh: Larry E. Taylor, Brandon C. Knott, John O. Baker, P. Markus Alahuhta, Sarah E. Hobdey, Jeffrey G. Linger, Vladimir V. Lunin, Antonella Amore, Venkataramanan Subramanian, Kara Podkaminer, Qi Xu, Todd A. VanderWall, Logan A. Schuster, Yogesh B. Chaudhari, William S. Adney, Michael F. Crowley, Michael E. Himmel, Stephen R. Decker, Gregg T. Beckham

Format: Article
Diterbitkan: Nature Portfolio 2018-03-01

Deskripsi

Cellobiohydrolases (CBHs) are critical for natural and industrial biomass degradation but their structure–activity relationships are not fully understood. Here, the authors present the biochemical and structural characterization of two CBHs, identifying protein regions that confer enhanced CBH activity.