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Allium ampeloprasum (leek) is a bulbous perennial edible vegetable closely related to garlic (A. sativum L.). In this study, the antinociceptive, antidepressant and anxiolytic effects of A. ampeloprasum were studied. A. ampeloprasum inhibited abdominal cramps in writhing test and increased latency time in hot-plate and tail-flick tests. In formalin test, A. ampeloprasum inhibited paw licking in both early and late phases. Propranolol, but not naloxone or yohimbine, reversed this effect. A. ampeloprasum decreased the number of lines crossed in open field test but has no effect on the time spent in open arm in elevated plus maze or the immobility time in forced swimming test. GC–MS analysis resulted in the identification of 18 compounds with phytol acetate, linoleic acid and tricosane as major constituents. In conclusion, the analgesic action of A. ampeloprasum was mediated by interaction with β-adrenergic receptor. No antidepressant or anxiolytic effects were exerted by A. ampeloprasum.